Karius and Mane start for Liverpool

first_imgLiverpool Liverpool team news: Karius and Mane start against Leicester City Melissa Reddy Liverpool FC Correspondent 22:00 12/30/17 FacebookTwitterRedditcopy Comments(0) Loris Karius Liverpool Premier League Liverpool v Leicester City Leicester City Jurgen Klopp has made five changes to his starting XI for the final game of 2017 with the Reds next fixture in just 48 hours Loris Karius gets his third Premier League start of the season with Sadio Mane also returning in Liverpool’s hosting of Leicester City on Saturday afternoon.The German replaces Simon Mignolet in goal, with the speedster switching in for Alex Oxlade-Chamberlain.Those are two of five changes Jurgen Klopp has made to the starting XI with a trip to Burnley to come on Monday. Article continues below Editors’ Picks Lyon treble & England heartbreak: The full story behind Lucy Bronze’s dramatic 2019 Liverpool v Man City is now the league’s biggest rivalry and the bitterness is growing Megan Rapinoe: Born & brilliant in the U.S.A. A Liverpool legend in the making: Behind Virgil van Dijk’s remarkable rise to world’s best player Dejan Lovren comes in for Ragnar Klavan at the heart of defence, Joe Gomez is at right-back with Trent Alexander-Arnold moving to the bench and James Milner replaces Gini Wijnaldum in the centre of the park.Liverpool starting XI: Karius, Gomez, Matip, Lovren, Robertson, Can, Milner, Coutinho, Mane, Salah, FirminoLiverpool subs: Mignolet, Klavan, Alexander-Arnold, Wijnaldum, Lallana, Oxlade-Chamberlain, Solanke Subscribe to Goal’s Liverpool Correspondent Neil Jones’ weekly email bringing you the best Liverpool FC writing from around the weblast_img read more

Roundtable: Underwood Love, KSU Fear and Those Throwback Helmets Need To Stay

first_imgHere at Pistols Firing, we use Slack to communicate back and forth. Sometimes this is constructive. Other times we riff for 20 minutes on Mike Gundy’s golf game. It’s going to be pretty slangy and GIF-y and not meant to be anything serious. We’re just here to talk about OSU the way we all do in real life. If you need to brush up on any of the contributors, you can do so here.Kyle Boone (Head of Crootin): Because I am curious, one word to describe your attitude toward OSU basketball?Kyle Cox (Contributor): One word? Optimi-realistic.Justin Southwell (Chief Uni Officer): Stoked. ?Sam Aldrich (Head of Hoops): Rowdy.Thomas Fleming (Xs and Os): Sanguine.Caleb Deck (Intern): Anticipatory? Is that a word? Anticipation-filled.Kyle Porter (Publisher): Mine is thrilled. KB can attest to this, but the last few years of watching and writing about games has been such a slog. It felt like, I dunno, work. Now I’m genuinely excited to tune in.Boone: A basketball post was one of the top reads on the site today!Caleb: I’d also say relief. Watching the Pitt St. exhibition in GIA was great and seeing the ball movement and spread offense and talent of the freshmen is more like what I remember as a kid and less like my collegiate years.Cox: I said this last night but I really think Waters is going to be good. Even with the level of competition plenty of true freshman would have had hesitation or mistakes and I didn’t see that from him one time. Looked like he knew where he was supposed to be on defense and was confident offensively. His length will help him on D as well.Fleming: I really do think they’re going to surprise people. And it’s a win-win because in this non-con schedule, they’ll be underdogs for a good amount of games (WSU, Maryland, etc.) and we’ll get to see how good this team can really be with no pressure or expectations.Aldrich: They’re going to struggle with lack of height inside, but you can go a long ways with that kind of a back court. Mitch is hugely valuable to this team, as terrifying as that is to say. Can’t be on the bench with two fouls five min. into the game like he was so often last yearCox: Right… N’Guessan is not ready, just in terms of size. Solomon still isn’t much of a bruiser anyway. McGriff can be useful cleaning up the boards but, like you said, undersized.Fleming: I think McGriff is the next Kamari Murphy. He’s going to be really important.Cox: He’s going the U? But, yeah I agree he’s important.Caleb: It looks like McGriff could be an amazing 4 if we can pick up a big boy to play the 5 in the next recruiting class or two.Fleming: Yeah the Netherlands transfer is not the answer. Anthony Allen 2016.Porter: @boonek, you know the basketball landscape pretty well — how will they fit in this year in the Big 12?Boone: After one game it’s hard to get a read especially against Pitt State, but they do look improved in pretty much every area. Better disciplined on defense and really good ball movement on offense. They nearly had 30 assists and hung 117 in the first exhibition, so thats encouraging to see team ball return.Southwell: Can we apply for whatever Perry Ellis did for Markel Brown? I feel like he should get another three years at least.Boone: Ha! Kansas is still going to run the show this year though.. I think OSU being picked 7th in preseason may be about right. This is still somewhat of a rebuild.Porter: You say “this year” like it’s not on repeat for the last decade. Does anyone else think we’re going to lose to KSU this week like I do?Cox: I feel like we have to force turnovers to get stops on D. So I’m torn at this point since its KSU.Boone: Nah, I think OSU comes back from Manhattan with a dub, surprisingly. In Mason we trust.Southwell: We have too much momentum to lose to KSUCaleb: I think Pokes can win this weekend. Originally thought we wouldn’t and I still think it will be tougher than it may appear, but with Mason really tightening up those short-intermediate throws I feel more confident.Steven Mandeville (Contributor): Gosh, if they hadn’t given us a run for our money with a wide receiver at qb at home I’d feel pretty good. They always play us well (they win in manhattan, take us to the wire in Stillwater). Scared they won’t pass it enough for Ramon to get enough shots at an interceptionPorter: Does Oklahoma State play OU for the Big 12 title in Norman? (i.e. win out and Baylor lose at least one other game)Carson Cunningham (podcasting): They are already talking about OU.screen-shot-2016-11-02-at-3-44-14-pmCox: Ehhhh… yesssss???Boone: No. I don’t think Baylor will lose again, and I think OSU trips up before their showdown in Norman. TCU in Fort Worth will be tough, with or without Kenny Trill.Aldrich: I’m gonna say no. Pokes lose once more before then, and I don’t know if Oklahoma will lose again (before they get inevitably stomped in a bowl, of course).Southwell: It wouldn’t surprise me if that happened. Maybe I’m too high on the performance against WVU, but if they continue to play like that, OSU can win out.Aldrich: And to answer @porter yeah, I do kind of feel a loss coming this weekend. K State absolutely refuses to turn the ball over, and our defense is pretty reliant on TOss. Mixed with Road Mason, and The Windbreaker at home, not very confident.Caleb: I think it’s definitely possible but I’m not sure of the likelihood. Baylor still has TCU, @OU, KSU, TTU, and @WVU. That’s no cake walk and I think they lose, but I’m not sure about the Pokes. We have the potential but I’m not fully confident in us holding our nerve on the road so much.Thomas: The chances of OSU going big 10 again are high in my opinion. They’re not going to go tempo and let KSU control the clock the entire game. Too strenuous for defense.Cox: That would be good as long as they don’t commit turnovers. Solid strategy… Hope it works.Mandeville: I don’t think so, the league is really open at this point but this feels so much like 2010 it’s not even funny.Porter: Last one — is the Homecoming black helmet your new favorite? If not, where does it rank?Cox: It’s the best one they have in my opinion.Porter: “In our opinion”Carson: “You let us make that decision!”Cox: They could do an orange/white or white orange or even black/orange and make my life complete. Actually, that should be the only helmet design and all others should be considered alternates. Hope I’m not being too vague.Carson: It’s top 5. I’m a matte black homer. Best helmet look they have.Cox: I’m saying make last week’s an orange sticker and it’s all-time. Old School brand > new school brand. Not even close in our opinion.Caleb: Gosh this is a brutal question. I think if it was the classic orange OSU on white shell it would be totally unstoppable for me. I loved the bronco rider helmet too, but i’ve always had a penchant for the Oklahoma A&M era stuff (that was kind of in the transition time of A&M to State). I think the 80s logo is still my favorite though, even in white/chrome on black.Fleming: Top 5. I do love it a lot.Aldrich: Easily top 5. I’m a sucker for anything throwback.Porter: Me too.Southwell: It’s great. I’m ready to rank the helmets again at the end of the season. I’ve really become a fan of the white alt – black brand w/ black stripe. (Iowa St 2013) So that might be my number 1 now. But I’ve always loved the black helmet with the Bedlam win and Fiesta Bowl win. I’d say it’s top 3, and I’d love to see the updated white logo (carbon fiber) on a matte black helmet.Caleb: I would still prefer this over anything ever. Ultimate Oklahoma State logo.screen-shot-2016-11-02-at-3-52-27-pm While you’re here, we’d like you to consider subscribing to Pistols Firing and becoming a PFB+ member. It’s a big ask from us to you, but it also comes with a load of benefits like ad-free browsing (ads stink!), access to our premium room in The Chamber and monthly giveaways.The other thing it does is help stabilize our business into the future. As it turns out, sending folks on the road to cover games and provide 24/7 Pokes coverage like the excellent article you just read costs money. Because of our subscribers, we’ve been able to improve our work and provide the best OSU news and community anywhere online. Help us keep that up.last_img read more

Watch: Mike Gundy Talks Mullets With Barry Melrose

first_imgWhile you’re here, we’d like you to consider subscribing to Pistols Firing and becoming a PFB+ member. It’s a big ask from us to you, but it also comes with a load of benefits like ad-free browsing (ads stink!), access to our premium room in The Chamber and monthly giveaways.The other thing it does is help stabilize our business into the future. As it turns out, sending folks on the road to cover games and provide 24/7 Pokes coverage like the excellent article you just read costs money. Because of our subscribers, we’ve been able to improve our work and provide the best OSU news and community anywhere online. Help us keep that up. Mike Gundy went on SportsCenter with Barry Melrose on Tuesday evening to talk, well, mullets. Melrose (who is a mullet connoisseur if there ever was one) asked Gundy about how his family feels about the locks.“My wife kind of likes it,” said Gundy. “Now my boys … they were a little skeptical about me maybe embarrassing them in front of their friends. I have a 20-year-old in college, and he thinks it’s pretty cool.The best part was Gundy talking hair product. On national television.“It’s a little bit of butch wax,” said Gundy of what he uses to tame the mane. “You’re right. You gotta have good genes. You gotta have great hair. You have to make sure you have the right product. There’s a lot of pressure when you have hair like this. You have to make sure it looks right.”ICYMI: @CoachGundy went on @SportsCenter with @nhlbarrymelrose to talk mullets and it was just as funny as you thought it would be. pic.twitter.com/7q5dYG28IL— Cowboy Football (@CowboyFB) February 22, 2017last_img read more

10 months agoInter Milan offered Bayern Munich veteran Arjen Robben

first_imgInter Milan offered Bayern Munich veteran Arjen Robbenby Carlos Volcano10 months agoSend to a friendShare the loveInter Milan have been offered Bayern Munich veteran Arjen Robben.Off contract in June, Robben has announced he is leaving Bayern at the end of the season.The Dutch midfielder has opened the door to a return to PSV Eindhoven, however FcInterNews.it says agents have also offered him to Inter.While now 34, Inter management have welcomed the approach and are actively discussing adding Robben to the squad next season.Though Inter are keen to drive down the average age of their squad, they’re willing to make an exception for Robben. TagsTransfersAbout the authorCarlos VolcanoShare the loveHave your saylast_img

Cardale Jones Addresses “Fans” Who Were Trashing Him On Twitter

first_imgCardale Jones pumping up the crowd before the game.Cardale JonesOhio State quarterback Cardale Jones hasn’t played up to his potential this season, and many Buckeyes fans have been vocal about their desire for head coach Urban Meyer to make a change at the position. Unfortunately, far too many are expressing their opinions the wrong way.Following Ohio State’s narrow victory over Indiana this past Saturday night, Jones celebrated the team’s win on Twitter. Some of the responses he got were beyond offensive. Tuesday, he addressed the “fans” who decided to trash him online. He clarified that they’re “haters”, not fans.@CJ12_ I’m sorry for all of the idiotic responses you get from so called “fans”— Chad Proud (@cproud13) October 6, 2015 RT: *haters https://t.co/H6bcaErCe5— Cardale Jones (@CJ12_) October 6, 2015 Rome wasn’t built in a day— Cardale Jones (@CJ12_) October 6, 2015 Jones will get another chance to silence the haters Saturday against Maryland.last_img read more

DEBATE HIGHLIGHT All 5 Candidates Pledge To Carry On Micelis Legacy Of

first_imgWILMINGTON, MA — All five Democratic candidates in the 19th Middlesex State Rep race pledged to continue Jim Miceli’s legacy of superior constituent services, during last week’s debate hosted by Wilmington Community Television and moderated by Katie Lannan of State House News.“The biggest part of Representative James Miceli’s legacy is his level of constituent services,” said former Wilmington Selectman & School Committee member Judy O’Connell (D-Wilmington). “I will be a leader that listens and a voice for the people. I believe that I have the human qualities and the core qualities and attriubutes of an ideal state representative. I have the intellectual ability, the biggest heart, and invested myself for decades into this community through a myriad of philanthropic endeavors. I believe I have the ability to build consensus. I have a past demonstrated track record of helping people. I will be accessible, transparent, and actively engaged on behalf of all residents regardless of their issue or concern.”“When I think of James Miceli, I think of what he has done for so many people of so many ages for so many reasons,” continued O’Connell. “It would be my honor to follow in his footsteps, most specifically, in that regard, to take care of all people in the 19thMiddlesex district.”“I don’t think anyone sitting here will fill the shoes of my uncle, Jim Miceli. He’s going to go down as perhaps the best representative Wilmington and Tewksbury has ever seen,” said 28-year Wilmington Selectman Mike McCoy (D-Wilmington.) “That being said, I do bring something to the table. I’ve served my government for 31 solid years – 28 years as a member of the Board of Selectmen and 3 years on the Planning Board. I’ve demonstrated constituent services and accessibility. People know how to get in touch with me.“I really truly believe public service is in my DNA,” added McCoy. “I love helping people through the maze of local government. I believe I can take what I’ve done and learned at a local level and bring it and excel at the state level. I care about people. I’ve been in the people business all my life. I really enjoy helping folks. If I can help someone make a better life for themselves, I’m going to do that. There will be a learning curve, I will learn from my mistakes, and I will move forward. I know I can do this.”“Jim was a good friend. I would talk to him 3-4 times a week. He’d always have me on the phone about something going on in Tewksbury or Wilmington. The two of us shared the same thoughts,” said Tewksbury Selectman Mark Kratman (D-Tewksbury). “I’m out every single night at some event – doing everything I can for the community. Everytime I was there, Jim was there. The two of us would be going around, talking with people.”“Since his passing, I’ve received over a hundred phone calls from folks who said they’d usually call Jim, but they’re calling me because they need help,” continued Kratman. “When people call and they’re at their worst, and need you the most, you’re supposed to be there to help them. That was the best thing Jim Miceli would always do. He took care of everybody. Everyone at this table has at least 100 stories of how Jim helped everybody. I want to be the same type of person that he was.”“I echo everyone else’s comments about constituent services,” agreed Wilmington Democratic Town Committee Chair Erika Johnson (D-Wilmington). “When I interned from Rep. Miceli, I was at the beginning of my political science career in college. I was really unsure of what path I wanted to take. Interning for him, he had me working on everything, from summarizing bills to going to committee meetings with him. The consistuent services aspect was the one that stuck with me. The power of that office and what you can do to make an impact in people’s lives really stuck with me.”“I’m the type of person that’s motivated by making a difference in someone else’s life and contributing to the greater good,” added Johnson. “Every single person I talked to on the campaign trail has had a story about how Representative Miceli helped themselves, a family member, a friend or a neighbor. That’s something that absolutely needs to be continued. I will be accessible, transparent, and there for anyone who needs my ear.”“It’s nice to hear all [these responses] because, in a sense, for four to five years, I was the man behind the man as my title was ‘Officer of Constituent Affairs’ for Representative Miceli,” said former Miceli Chief of Staff Dave Robertson (D-Tewksbury). “Jim was accessible at all hours. I kid you not. If I could have charged him double for picking him up at 2am, I would have, but out of love and dedication, I didn’t.”“Because he had so many people looking to him for help, he had to split the load between my good co-worker and I. Over that time, I – personally – was able to assist the representative and quite often took the lead on issues… I found hundreds, if not thousands, of different solutions to people’s cases over the years,” continued Robertson. “I have worked with local, state and federal agencies to the point where I can pull out my cell phone, turn it on, call these people, and have a first-name conversation. That’s how well I know these constituent affairs folks. I am the most knowledgeable when it comes to helping [a constituent] one-on-one.”Watch the debate, courtesy of Wilmington Community Television, below. Jump to the 1:06:30 mark to watch much of what was written above.—Video Playerhttps://objects-us-west-1.dream.io/wilmington/e/f/b/2/2/6/efb2269b-0049-4395-88c5-1a6b7753f1841535028088.523%2B39810787.566%40castus4-wilmington%2B15350318121535028264454752.vod.720p.180823%20Democratic%20Primary%20Debate.mp400:0000:0000:00Use Up/Down Arrow keys to increase or decrease volume.—Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email wilmingtonapple@gmail.com.Share this:TwitterFacebookLike this:Like Loading… RelatedDEBATE HIGHLIGHT: Most Democratic Candidates Not Ready To Pledge To Support Their Party’s Nominee In General ElectionIn “Government”STATE REP RACE Q&A: Judy O’Connell Discusses State Rep Pay, Environmental IssuesIn “Government”STATE REP RACE: Judy O’Connell Addresses Allegations Of Federal Tax Liens On Her HomeIn “Government”last_img read more

Through a Sensor Holographically

first_imgThis pixel superresolution approach effectively increases the sensor pixel density without physically adding additional pixels or sacrificing the imaging field of view (FOV). This is accomplished by capturing different images resulting from motion of either the illumination source or the sample and subsequently merging these lens-free frames to synthesize a higher spatial resolution holographic image. In microfluidic applications, for example, the fluidic motion of objects flowing by the sensor array can be used to generate high-resolution holograms. Ozcan acknowledges that a fundamental challenge to transmission optical microscopy in general (whether lens-based or lens-free) is photon scattering when imaging thick tissue samples. “However,” he adds, “I expect that this limitation can be partially released if the scattering properties of tissue were to be reduced through some sample preparation steps – at least for certain class of objects. There is some very promising work in the literature around this major issue and researchers are working hard with various innovative schemes toward this end.” Ozcan sees the primary applications of lens-free microscopy being in cell and developmental biology – especially in microfluidic integration. “Microfluidic integration would permit rather interesting lab-on-a-chip devices that could do optofluidic microscopy and tomography (also referred to as holographic optofluidic microscopy, or HOM) on the same chip. This way the compact and cost-effective platform of lab-on-a-chip devices could be coupled with high-resolution 3D micro-analysis tools on the same platform.”In fact, Ozcan has done previous work in lens-free opto-fluidic microscopy, last year publishing a paper with Dr. Waheb Bishara and Dr. Hongying Zhu entitled Holographic Opto-Fluidic Microscopy (Optics Express 18:27499–27510, 20 December 2010, Vol. 18, No. 26). In that paper, the authors note that their HOM platform does not involve complicated fabrication processes or precise alignment, nor does it require a highly uniform flow of objects within microfluidic channels. Relatively recently the Ozcan group has also demonstrated, for the first time, optofluidic tomography, soon to be published in Applied Physics Letters. Of great interest is that when asked if further miniaturization and integration – such as an on-chip partially-coherent light source – could potentially enable in vivo applications, Ozcan did not rule out the possibility. “Over the last decade microfluidics has created a versatile platform that has significantly advanced the ways in which microscale organisms and objects are controlled, processed and investigated, by improving the cost, compactness and throughput aspects of analysis. Microfluidics has also expanded into optics to create reconfigurable and flexible optical devices such as reconfigurable lenses, lasers, waveguides, switches, and on-chip microscopes.” This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. (PhysOrg.com) — The power and resolution of lens-based optical microscopes have improved by orders of magnitude since their invention around 1595. Nevertheless, relying on a high-magnification lens for image clarity has limitations that become more relevant as larger and larger sample volumes need to be viewed. Moreover, achieving these advances in lens-based optical microscopy has increased their size and complexity. At the same time, microfluidic systems are becoming increasingly sophisticated while decreasing in size, creating a need for miniaturized optical microscopy that can be integrated onto a lab-on-a-chip to allow simultaneous analysis and imaging of small biological samples. (A1) A single, low-resolution (LR) hologram obtained by vertical illumination of 10μm beads in a chamber. (A2) Zoomed region from the LR hologram, showing the aliasing effect due to undersampling of high-frequency interference fringes. (B1) A digitally synthesized pixel superresolved (SR) hologram using multiple subpixel shifted LR holograms. (B2) Zoomed region from the SR hologram, showing the digitally recovered high-frequency fringes. The inset shows the profile along the dashed line on the SR hologram, where an interference fringe with 2.8μm period is recovered with high SNR, which is normally undersampled by the detector with a physical pixel size of 2.2μm. (c) PNAS, doi:10.1073/pnas.1015638108 Copyright 2010 PhysOrg.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed in whole or part without the express written permission of PhysOrg.com. Optical microscope without lenses produces high-resolution 3-D images on a chip Enter Prof. Aydogan Ozcan, associate professor of electrical engineering at UCLA’s Henry Samueli School of Engineering and Applied Science. Ozcan and his team – notably lead researchers Serhan Isikman and Dr. Waheb Bishara – have created a lens-free chip and image processing algorithm that utilizes optical sensors, holography and digital tomography combination to render high-resolution, high-contrast images while avoiding the limitations of standard lens-based optical microscopy. “The sensor,” Ozcan notes, “is an inexpensive five megapixel CMOS chip, 5MP with a 2.2 micrometer pixel size. It’s almost the same sensor that we have at the back of a Blackberry or iPhone, except that it’s monochrome rather than RGB.”One of the biggest challenges facing the team was reducing noise artifacts resulting from spatial and temporal coherence due to illuminating the sample with lasers – especially at oblique angles. This coherence-induced noise appears as speckling patterns that obscure images of the actual sample structure. The team addressed the issue by replacing laser illumination with partially-coherent light that emanates from a large aperture of ~0.05-0.1mm diameter with a bandwidth of 1-10 nm, finding that recording in-line holograms using partial coherence provided a gating function which allowed the device to filter noise beyond a defined resolution level. Using partially-coherent light provided a high signal-to-noise ratio (SNR) that dramatically improved clarity and legibility of fine structural details. Moreover, the team developed a sample illumination approach that rotates the partially-coherent light source around the sample, rather than requiring the sample platform to be rotated within the illumination field, which is rather inconvenient to achieve practically, especially for large sample volumes. Ozcan comments that, of the many innovations in this lens-free optical tomographic microscope, three are key: partially-coherent illumination with unit-magnification; pixel superresolution to achieve deeply subpixel lateral resolution; and dual-axis tomographic illumination. In their setup, dual-axis illumination is achieved by rotating the light source using a motorized stage; alignment is not sensitive and robustness is maintained. At every illumination angle, a series of subpixel shifted holograms are recorded for implementing pixel superresolution, such that submicron lateral resolution can be achieved even under unit fringe-magnification. “The chip uses dual-axis illumination to mitigate our limited angles of illumination such that a decent axial resolution can be achieved. The spatial frequencies that are collected from each axis is merged together to fill in some gaps in the 3D Fourier spectra of our objects. Moreover,” he adds, “this is the first time that dual-axis illumination has been applied in optical computed tomography schemes.” Explore further More information: — The Ozcan Research Group at UCLA innovate.ee.ucla.edu/– Lens-free optical tomographic microscope with a large imaging volume on a chip, PNAS Published online before print April 19, 2011, doi: 10.1073/pnas.1015638108– Holographic Opto-Fluidic Microscopy, PubMed, doi: 10.1364/OE.18.027499 — Optical microscope without lenses produces high-resolution 3-D images on a chip www.physorg.com/news/2011-04-o … gh-resolution-d.html Citation: Through a Sensor, Holographically (2011, April 26) retrieved 18 August 2019 from https://phys.org/news/2011-04-sensor-holographically.htmllast_img read more

Small is beautiful Viewing hydrogen atoms with neutron protein crystallography

first_img Research Professor Julian C.-H. Chen discussed the group’s research with Phys.org, first summarizing the main challenges they faced in overcoming the limitations of only X-ray crystallography, visualizing hydrogen atoms a three-dimensional context, determining protonation states of active site residues in enzymes, and establishing the identities and orientation of solvent molecules. “The strength of neutron crystallography lies in its ability to locate hydrogen atoms in macromolecular structures. Hydrogen accounts for one-half of the atoms in any given protein, and help perform all sorts of tasks, from hydrogen bonding to catalysis,” Chen explains. “For X-ray crystallography, locating hydrogen atoms is especially difficult as they possess just one electron, and X-rays are weakly scattered by hydrogen atoms compared to other elements in proteins such as carbon, oxygen, nitrogen, and sulfur.”Furthermore, hydrogen atoms in protein structures can be quite mobile. “You’re lucky to be able to see them even in the highest resolution structures,” Chen continues. “Neutrons, on the other hand, have the nifty property that deuterium, which can be introduced into reactive sites on the protein through hydrogen/deuterium exchange, scatters neutrons so they are easily located and readily visible in nuclear density maps, even at moderate resolution. So this makes it relatively straightforward to determine protonation states of residues. Similarly, for solvent molecules, D2O, or heavy water, can be introduced into the crystal – and these molecules have an easily identifiable boomerang shape in the nuclear density maps, which makes it possible to orient them.”On addressing these challenges, Chen adds, “We reasoned that if we had the combination of ultrahigh resolution and neutron diffraction data on hydrogen/deuterium-exchanged crystals, we should be able to describe how individual deuterium atoms vibrate – and not only that, but also describe their anisotropic vibrational motion.” (An anisotropic material exhibits different values of a property in different crystallographic directions.) “So that’s exactly what we did for a number of selected deuterium atoms within crambin – a protein that forms the best-ordered macromolecular crystals known. We surmised that crambin crystals would diffract neutrons to ultra-high resolution as well.” (Phys.org)—Creating 3D visualizations of hydrogen atoms in proteins is especially challenging, often requiring their locations to be inferred from those of nearby carbon, nitrogen, oxygen or sulfur atoms stored in protein structure databases. These locations are based on atomic positions in databases of previously solved structures, general chemical knowledge, quantum mechanical calculations, or potential hydrogen bonding interactions. While X-ray crystallography can pinpoint hydrogen atom locations at ultrahigh resolution, in practice only a few such positions are experimentally determined. Recently, however, scientists at the University of Toledo, Los Alamos National Laboratory and Oak Ridge National Laboratory used neutron crystallography – a technique that even at lower resolutions can locate individual hydrogen atoms by leveraging scattering properties of the hydrogen isotope deuterium. More information: Direct observation of hydrogen atom dynamics and interactions by ultrahigh resolution neutron protein crystallography, PNAS September 4, 2012, doi:10.1073/pnas.1208341109 Explore further Structure of enzyme against chemical warfare agents determined Copyright 2012 Phys.org All rights reserved. This material may not be published, broadcast, rewritten or redistributed in whole or part without the express written permission of PhysOrg.com. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Journal information: Proceedings of the National Academy of Sciences As Chen points out, crambin is a small protein with a limited number of deuterium atoms. “Especially with the new neutron crystallography instruments under construction or being commissioned, new datasets of similar or higher resolution should be possible with crambin as well as other proteins. We’re of course staying updated on these developments.” Chen adds that some of their findings pertaining to hydrogen/deuterium exchange can also be addressed by other physical methods.Chen also comments on their key findings provide the ability to inventory all hydrogen bonding interactions within the protein and ascertain the categories and suggest strengths of hydrogen bonds in the system; demonstrate the power of ultrahigh resolution neutron diffraction to resolve ambiguous hydrogen bonding networks; and reveal unconventional structural features and interatomic interactions. “You generally only see the oxygen of the water in X-ray structures, keep in mind that the two hydrogens scatter X-rays weakly and are generally invisible.” This means that the hydrogen bonding networks can be ambiguous. “But with neutrons,” Chen continues, “since you get strong scattering from the deuteriums of the D2O, you can orient the hydrogens and figure out the network of hydrogen bond donors and acceptors.”Moreover, says Chen, the researchers also saw some instances of unusual hydrogen/deuterium exchange patterns. “One residue in particular appeared to have hydrogen/deuterium exchange on one of the hydrogens bonded to the alpha carbon. This could be evidence of C-H. . .O hydrogen bonds, which are rather elusive and difficult to observe experimentally although nearly 30 years of mostly computational work have been done on these hydrogen bonds.”In terms of other research and downstream technology might benefit from your findings, Chen stresses that their study demonstrates what can be done with neutron crystallography. “I think that this, and future structures, will give the humble hydrogen atom its due,” Chen concludes. “This will hopefully work its way into computational algorithms that address protein-ligand and protein-drug interactions. This work may also lead in the long run to more accurate, higher quality macromolecular structures.” (A) Structure of crambin, with main chain amide hydrogen/deuterium (H/D) exchange pattern ranging from blue (unexchanged) to red (fully exchanged). (B) Side chains of residues R10, N14, N46, and T2 are depicted with anisotropic ellipsoids. D atoms are shown in green, with hydrogen bonds indicated. Copyright © PNAS, doi:10.1073/pnas.1208341109 Citation: Small is beautiful: Viewing hydrogen atoms with neutron protein crystallography (2012, September 20) retrieved 18 August 2019 from https://phys.org/news/2012-09-small-beautiful-viewing-hydrogen-atoms.htmllast_img read more

North 24Parganas district admin cracks down on illegal filling up of water

first_imgKolkata: North 24-Parganas district administration has cracked down on the illegal filling up of water bodies across the district following instructions from the Urban Development Department.It had issued an instruction to the top brass of the North 24-Parganas district administration asking them to take stringent actions against filling up of water bodies and ponds that are often reported from various places.The matter was also taken up during an administrative meeting convened by Chief Minister Mamata Banerjee in Barasat a few months ago where Banerjee instructed the administrative officials to strongly deal with the issue. Also Read – Rain batters Kolkata, cripples normal lifeThe land and land reform officers in all the Sub-divisions have been asked to keep a tap on the water bodies so that corrupt practices could be checked.All the municipalities in the districts have also been asked to take strong steps if any complaints regarding filling up of water bodies come up from any particular area.The municipalities have also been instructed to carry out renovation works of the ponds and water bodies that are in bad shape. The district administration has already taken actions and checked the illegal filling up of water bodies in the various sub-divisions. Such incidents are often reported from various places under Barrackpore Sub-Division. Also Read – Speeding Jaguar crashes into Mercedes car in Kolkata, 2 pedestrians killedA senior administrative official from the district on the conditions of anonymity said illegal filling up of the water bodies have been stopped at various places in the district. Appropriate steps are being taken against the accused under inland fisheries Act and land and land reforms Act.It may be mentioned here that allegations of illegally filling up of water bodies not only surface from Barrackpore but also from other sub-divisions. The latest recent incident was reported from Barasat where an attempt was made to fill up a pond illegally. A guard wall was constructed around the pond with an intention to fill up the pond. Locals submitted a mass petition to state secretariat at Nabanna following which the district administration was directed to take appropriate steps in this regard. A case has been started under Land Reforms Act to preserve the pond.The officials from Barasat Municipality recently visited the spot and stopped the illegal construction around the pond. According to Barasat Municipality Chairman Sunil Mukherjee, illegal construction around the pond has been stopped and all necessary steps are being taken for the proper preservation of the pond. The municipality will also take up beautification works around the pond. State Urban Development Minister Firhad Hakim on Wednesday in the Assembly said steps have been taken to ensure proper preservation of water bodies. He also alleged that during the Left Front regime, water bodies were rampantly filled up destroying the ecological balance.last_img read more

Colours of Patriotism

first_img‘Spandan– The colours of India’, curated by Rajan Arora is a group art show by 8 eminent contemporary artists – Niren Sengupta, Niladri Paul, Alka Raghuvanshi, Sudip Roy, Nupur Kundu, Shridhar Iyer, Hem Raj and Manisha Gawade,  which will present art works brushed in the spirit of patriotism. The colorful abstract canvases presented by each artist narrate a special story. ‘Spandan’ means creativity and all the works are aesthetic in the selection of colour, there is a positive energy that underlines each work and has the ability to energise any space they are placed in.“I feel that abstract art needs no introduction to “understand” for it is not difficult – all it needs is to be viewed with the heart, the mind will follow and make the connection effortlessly.  Anyone who has come to the point of acquiring art for the sheer reason of its own sake comes with proclivity and inclination towards art and usually has refined aesthetics. And if it means getting art that is also good long-term investment, then it is a win-win for all,” says Rajan Arora, the curator who has brought the artists together.  The joyous colours that are the hallmark of Niren Sengupta’s perspective ensure a spiritual quest to his paintings that just seems simple on the first glance but are layered with profound meaning. Alka Raghuvanshi’s lifelong connection with classical dance bestows a rare fluidity to her work that sets it apart. Niladri Paul’s works are bright yet subtle and he is a rarity of sorts where he is in the throes of coming from a platform of figurative to the abstract. Shridhar Iyer’s works are essentially a sum of his spiritual journey, very masculine and stark in their colour palette but completely of international quality in their approach. Nupur Kundu’s work is a remarkable balance of the tandava and the lasya or male and female energies that is almost primordial in its manifestation. Manisha Gawade focuses on relationships and her work is an aesthetic blend of several types of techniques garnered over the years to trace her journey transcending time and space.When:  August 10-15Where: Visual Arts Gallery, India Habitat CentreTimings:  11 am till 7 pmlast_img read more

PhotoTaking Contact Lenses Giant Crab Robots and RadiationBlocking Underwear

first_imgMay 20, 2014 Teeny tiny tech with a big punchAs technology becomes more advanced, the size of our tools and gadgets gets smaller. In some instances, super small.The latest example: solar cells the size of the period at the end of this sentence, developed by North Carolina-based Semprius.So, they’re extremely small.  Now get this: Solar panels you commonly see on houses and buildings are 20 percent or less efficient at converting the sun’s energy into electricity. Semprius’ super-small solar panels convert between 35 percent and 44 percent of the sun’s energy into electricity, the startup says.Read more: Check This: Solar Cells the Size of a Pencil Point Get ready. Here comes more robots.Google is developing driverless cars. So how about personal robots to help us with our chores and keep us company?Have patience. They’re coming.If you ask Brian David Johnson, the resident futurist at tech-giant Intel, personal robot companions could become a reality sooner than you think. Johnson took it upon himself to build his own robot pal named Jimmy, one that is 3-D printed and operating on open-source code.Apparently Johnson is quite smitten with Jimmy and thinks we’ll all have robot friends in the near future.Watch: No Sci-Fi Here: Your Own Personal Robot Is Coming Luke Skywalker, eat your heart outOr in this case, your hand off. OK, never mind. Gross.The FDA recently approved a mind-controlled prosthetic limb the has the same weight and shape as an adult arm. It was designed by Dean Kamen, the guy who invented the Segway.Kamen’s company, DEKA Research and Development, has nicknamed the limb Luke, after Luke Skywalker. The company says that 90 percent of people who participated in a study were able to perform activities using Luke that they couldn’t do with their current prosthesis. Stuff like using keys, preparing food and feeding themselves.So, so cool.Read more: FDA Approves First Mind-Controlled Prosthetic Arm Free Webinar | Sept 5: Tips and Tools for Making Progress Toward Important Goals Photo-snapping contact lensesThe Army isn’t the only one innovating the traditional contact lens. Tech-giant Google has filed a patent application for a micro-camera component that could work with contact lenses.Essentially, Google wants to develop tiny cameras that can be embedded into contact lenses. The idea is that wearers could snap pictures simply by winking.Hmm. Creepy.Google is already said to be developing smart contact lenses that can track the glucose levels in a person’s tears.Read more: Google Wants to Patent Contact Lenses That Can Snap Photos Register Now » Attend this free webinar and learn how you can maximize efficiency while getting the most critical things done right. A bright idea for dark placesI hate driving at night. And if it’s raining hard or snowing, fugetaboutit. I can’t see the lines on the road.Oh, wait, there’s a highway with glow-in-the dark lines, you say? Brilliant.Daan Roosegaarde, a Dutch interactive artist who is becoming known for taking everyday items and giving them visually stimulating upgrades, has come up with a new project:  illuminate a 500 meter stretch of highway in the Netherlands with glow in the dark paint.The glowing lines are created using paint mixed with a “photo-luminising” powder. Basically, the paint soaks up the sunlight and releases a green glow at night. If this works better and more efficiently than street lights, let’s do it already.Read more: A Highway Illuminated by Glow in the Dark Paint, Not Streetlightscenter_img 6 min read Night vision … contact lenses!Speaking of seeing in the dark, the Army apparently has a cool new trick up its highly-funded sleeve. Say goodbye to bulky night-vision goggles and hello to featherweight night-vision enabled contact lenses.That’s right. Contact lenses that allow wearers to see in the dark. It’s in prototype phase at the moment, thanks to scientists at the University of Michigan’s College of Engineering. The practical, real-world value for something like this probably goes without saying.Read more: Eye of the Tiger: U.S. Army Eyes Night Vision Contact Lenses Ah, technology. What a wonderfully innovative, confounding, inspiring thing. Today, thanks to advances in tech, we have things like highways illuminated at night by glowing paint, musical houseplants and air-filtering billboards.Sound too good or too wacky to be true? Read on.We’ve rounded up 10 recent examples of technologies that are pushing the boundaries of innovation. We think they’ll make you scratch your head and say, “What the heck?” A billboard for more than just advertisingWe’ve seen digital signage that can actually interact with individuals, but this isn’t that. This is even cooler.Peru’s University of Engineering and Technology, in partnership with advertising agency FCB Mayo, has developed an air-cleaning billboard. You read that right. A billboard that sucks in dirty air, filters it through a water system, then spits out clean air. The school says one billboard is as powerful as 1,200 trees, producing 100,000 cubic meters of purified air.Now, that’s fresh.Read more: This Crazy, High-Tech Billboard Does More Than Just Display Ads No joke: radiation-blocking underwear Hey guys, those mobile gadgets you love are also hurting you manhood. Translation: Laptops and tablets in your lap get hot and can lower your sperm count.No bueno.British physics teacher Joseph Perkins set out to do something about this issue. He developed the Wireless Armour boxer briefs for men. These $60 cotton undergarments are lined with silver meshing that he says deflects electromagnetic radiation.High tech where it counts the most. Now, that’s a silver lining.Read more: Far Out: Radiation-Blocking Underwear Also Protect Men’s Fertility DJ houseplant on the ones and twosIf only your savoy cabbage could sing you a song. Well, it can. Kinda. Sort of.An art collective called Data Garden has developed something called the MIDI Sprout. The device gauges plant biorhythms and turns that feedback into a sort of “music.”“By spending time with your plants as they play music — music that is an expression of their physiological changes — you’ll find that your plants are as perceptive of their surroundings as you are,” the company says.Hmm. Just, hmm.Read more: This Contraption Transforms Houseplants Into Musical Instruments This crab can do ‘The Robot’Prepare to meet the mammoth mechanical crab of your nerdiest undersea dreams.Researchers in Korea have developed the Crabster CR200. This thing is a 1,400-pound autonomous robot crab. Its designers believe that it can dive to underwater depths of 656 feet and will be instrumental in mining underwater shipwrecks and other amphibious tasks.Imagine encountering this thing while underwater diving? Yikes!Read More: Giant Crab-Like Robot to Plumb the Ocean for Shipwrecks and Treasurelast_img read more

PEOPLE Before Profit Councillor Shaun HarkinPEOPLE

first_img PEOPLE Before Profit Councillor Shaun HarkinPEOPLE Before Profit representatives will bring forward a motion at the first full council meeting of the term calling for the “scrapping” of welfare reforms to be made a red-line issue in talks devised to restore power-sharing.The motion will come from new PBP councillors Shaun Harkin and Eamonn McCann who were elected in May for Derry City and Strabane District Council. Said Cllr Harkin: “This Thursday (June 27) is the first full Council meeting since Eamonn and I were elected. “We are bringing a motion calling for Derry and Strabane Council to demand scrapping welfare reforms be a red-line in Stormont talks.“Stormont inflicted Tory welfare reforms on communities along with the RHI racket and corporate tax cuts. We need to send a message to the talks that welfare reforms must be scrapped and replaced with a humane alternative.“Stormont can’t continue as it was – implementing vicious cuts and running RHI rackets. “We’re also proposing the creation of a Council action committee involving trade unions, community groups, advice organisations and other relevant bodies to put the weight of the Council behind getting people help now and to undo the damage welfare reforms have done.“Cliff Edge NI is calling for welfare mitigations to be extended when they expire in March 2020 so that tens of thousands of people aren’t forced to pay the Bedroom Tax. “We’re backing this – but the Bedroom Tax is already here and should be abolished. “Welfare mitigations didn’t protect people from the hardship inflicted by Universal Credit, PIP, and other draconian policies. Hundreds of people already pay the Bedroom Tax here. “We won’t leave people and communities who’ve already been hammered by welfare cuts behind.“Universal Credit has been a disaster and must be shown the door along with sanctions, the two-child policy and the benefit cap. “Capita and ATOS, private companies profiting from causing misery in medical assessments must be kicked out.“We’re asking people to back the motion and join us at 3.30 pm at the Guildhall on Thursday. “Make your voice heard,” he added.People Before Profit councillors to oppose welfare reform at first full council meeting was last modified: June 24th, 2019 by John2John2 Tags: ShareTweet BEDROOM TAXCouncillor Eamonn McCannCouncillor Shaun HarkinDerry and Strabane CouncilGuildhallPeople Before Profit councillors to oppose welfare reform at first full council meetingUNIVERSAL CREDITlast_img read more

first_img — Recommended Links •  Smart investors know that owning gold is only the first step in crisis-proofing your wealth… We recently published an entire book about safeguarding your wealth against financial disasters. It’s called Going Global 2015, and it includes some of the best research we’ve ever published. This book is jam-packed with easy-to-understand tips and strategies you can use now…no matter where you live or how big your portfolio is. We normally sell Going Global for $99. But right now we’re practically giving this book away. We only ask that you pay $4.95 to cover our processing costs. Click here to claim your copy. •  Switching gears, Walmart (WMT) just delivered some bad news… Yesterday, at its annual investor day, the retail giant said it expects profits to fall 6-12% next year. Walmart’s stock plummeted 10% on the news. This was Walmart’s biggest single-day drop in nearly three decades. The sell-off erased $21 billion in market value. In a company note, Walmart’s CEO said that rising wages are eating into company profits. Walmart gave raises to 500,000 employees earlier this year. The company started paying its entry-level employees $9 per hour, $1.75 above the federal minimum wage. Next year, the company plans to lift starting wages to $10 per hour. But Walmart’s sales aren’t growing fast enough to cover its rising costs. Walmart’s sales grew just 2% last year. This year, Walmart doesn’t expect sales to grow at all. •  Walmart also announced a $20 billion share buyback program yesterday… A buyback is one of the only ways Walmart can reward shareholders right now… A share buyback is when a company buys its own stock back from shareholders. Share buybacks cut the number of shares a company has on the market, which ups its earnings-per-share (EPS). Buybacks can make a company’s financial results look better on paper. This can help push a stock’s price higher…but it doesn’t create any real value. For the most part, buybacks only create the illusion of higher earnings. They’re a way for management to goose EPS figures without actually improving the business. Plus, money spent on buybacks is money that can’t be spent building new stores or developing new products and services. Share buybacks don’t actually help businesses grow. But regular readers know that companies in the S&P 500 are on pace to buy back nearly $1 trillion worth of their own stock this year. That would be an all-time record. •  In today’s mailbag, we share how the collapse in oil prices is affecting readers… Yesterday we told you about Williston, North Dakota, a once-booming oil town that’s quickly turning into a ghost town. Several readers wrote in with first-hand accounts of how the collapse in the price of oil is hitting the Bakken Formation and the rest of the U.S. oil industry. Craig W. says: I work in the production services side of the oil and gas business. My job requires me to crisscross the Basin, so I know it’s huge. Williston has been through a lot of booms and busts, and this is one of the biggest [busts]. Highway 85 was a lethal nightmare. Just a year ago it was busy, congested, and dangerous, with a lot of very tired drivers. There is so little traffic running now you can tell the impact of the slowdown. Donald G. says: I’ve worked for BP/Amoco for the past 34 years. I have lived on the western end of Houston since 1996. Houston has been hit very hard regarding layoffs. Work is conducted in Houston for every sector of the industry around the world, and all those sectors have been hit hard. But, there seems to be an interesting “economic momentum” pushing housing starts and small business openings here in the energy corridor. I recently asked my homebuilder why he was still building spec homes in the area, given all the layoffs and company consolidations taking place. His response was, “It’s what I do.” I took that to mean that if the banks are willing to loan him money for each house, he will build it. Chart of the Day Walmart’s stock just nosedived… Today’s chart shows the performance of Walmart’s stock over the past month. As you can see, Walmart’s stock had been climbing for the most part. Then it plummeted 10% yesterday… This was worst day for Walmart’s stock since 1988. It’s now down 30% this year. Goldsmith: Why I Work For Doug Casey Now—Eye-Opening Report from Former Stansberry Director Sean Goldsmith recently left Stansberry to work alongside one of the most influential economists in the world today, Doug Casey. There’s probably not another American alive today who has done as many international deals and learned as much about global economies, currencies, and the inner workings of foreign governments. “Now,” says Casey, “we’re on the cusp of a new and major crisis here in America, one that’s going to be much more severe, different, and longer lasting than what we saw in 2008 and 2009…” Goldsmith explains the full details here. Claim 1 Free Year of “Top 1%” by Oct. 15 Until Thursday, you can claim one year of access to multimillionaire James Altucher’s hugely popular new $2,500 research letter… which shows you how to make 100% to 500%, on the top ideas from the venture capital and hedge fund world. Click here for the full details.center_img – Regards, Justin Spittler Delray Beach, Florida October 15, 2015 We want to hear from you. If you have a question or comment, please send it to feedback@caseyresearch.com. We read every email that comes in, and we’ll publish comments, questions, and answers that we think other readers will find useful. Paul Singer says investors don’t hold enough real money… Singer runs Elliott Management, a hedge fund that manages $27 billion. Singer generated an average 14% annual return from 1977 to 2012. Remarkably, he only had two down years during that thirty-five year span. Yesterday, at a hedge fund conference in Israel, Singer said that gold is the only “real money.” He also said he’s surprised more investors don’t own gold right now. Like us, Singer thinks every investor should own gold: I like gold. I believe it’s under-owned. It should be part of every investment portfolio, maybe five percent. •  Casey readers know that gold is the ultimate form of wealth insurance… People have used gold as money for thousands of years. It has protected wealth through every kind of financial disaster imaginable, including economic depressions, stock market crashes, and world wars. The price of gold hit a three-month high on Monday. In fact, gold is up 7% in the last month alone. That includes a 1.3% jump yesterday. •  At the conference, Singer also said central banks’ easy money policies have “levitated” stocks and bonds… In December 2008, the Fed dropped its key rate to effectively zero. It’s left it there ever since. The Fed also launched its first quantitative easing program, in November 2008. QE is when a central bank creates cash and injects it into the financial system. It’s basically another term for money printing. The Fed followed it up with two more rounds of QE. When it finally stopped its last round of QE in October 2014, the Fed had pumped $3.5 trillion into the U.S. financial system. Like us, Singer thinks the Fed’s easy money policies are a big reason why stocks and bonds have rallied over the past seven years… The S&P 500 has climbed 126% since November 2008. Meanwhile, yields on 10-year Treasuries, corporate bonds, and municipal bonds are half of what they were seven years ago (bond yields fall as bond prices rise). •  Singer says investors now expect central banks to “solve” every financial crisis… He calls this “the cult of central banking.” But Singer isn’t confident central bankers will be able to fend off the next crisis. He shared his doubts in Elliott Management’s second-quarter letter: Central bankers may not have the tools to combat a renewed slump. After all, with interest rates already at or near zero almost everywhere in the developed world, what would be the effects of new rounds of QE, other forms of money printing … in more places? Like us, Singer thinks easy money policies have completely warped the economy. If history is any indicator, Singer says seven years of easy money will leave a scar: Unfortunately, history has shown that governments that have abused the power to create “money” have always, eventually, paid a huge price for their profligacy. •  Singer says say things will “go to hell” if central banks decide they haven’t done enough… With interest rates already near zero, central banks only have one way to keep the easy money flowing. That’s more QE. But more QE would probably only lead to more bad financial decisions. Easy money policies have already made it ridiculously cheap to borrow money. Americans have borrowed trillions of dollars to buy stocks, bonds, houses, cars, and college educations. The Bank of International Settlements says U.S. household, corporate and government debt jumped from 218% of gross domestic product (GDP) in 2007 to 239% last year. •  Eventually, easy money policies could erode the value of paper assets… But central bankers can’t destroy the value of gold. This is a big reason why Singer thinks it’s so important to own gold right now: Gold would do well if people felt they needed some real asset to protect against inflation, government policy and/or diversification from stocks and bonds.last_img read more

World Cup Wire WEDNESDAY

first_imgFOR ALL WORLD CUP MARKETS CALL STAR SPORTS ON 08000 521 321 [dropcap]W[/dropcap]elcome to the Star Sports World Cup Wire. Our daily 4.30pm update from the trading room at Star Sports with all the moves and offers for this evenings World Cup.Wednesday 18 JuneWORLD CUP PRICES5pm12/1 Australia 2/9 Netherlands 11/2 DRAW8pm8/15 Spain 9/2 Chile 16/5 DRAW11pm9/2 Cameroon 7/10 Croatia 11/4 DRAWWORLD CUP WIRE5/2 the three favs – ENHANCED PRICEDAILY GOALS EVENS 9 goals or more, 4/5 8 or lessBetting in running throughout – including all the late kick offslast_img

The Tech Industrys Real Problem With Diversity Is Clear Its Not The

first_img Tech apologists claim there are insufficient numbers of qualified women to hire. Which conveniently overlooks the hostile work environments now known to be pervasive. Add to Queue The only list that measures privately-held company performance across multiple dimensions—not just revenue. Next Article –shares 2019 Entrepreneur 360 List Elizabeth Ames SVP of Marketing, Alliances and Programs at the Anita Borg Institute Guest Writer Apply Now » Opinions expressed by Entrepreneur contributors are their own. 3 min read September 1, 2017 For women in Silicon Valley, 2017 has been a watershed year. We’ve seen women technologists share their stories of sexual harassment and bias, shocking industry outsiders and even many male colleagues. Susan Fowler’s blog post blew the lid off of Uber’s sexual harassment issues and hostile culture. Soon thereafter, a crew of female entrepreneurs turned a spotlight on blatant sexual harassment in the venture capital world. Neither of these stories surprised women or minorities who work in tech, but—finally—people were listening.Related Video: See Inclusion as a Growth StrategyThe antidiversity screed penned by ex-Google engineer James Damore isn’t so surprising, either. As women and members of minority groups speak out and make gains, it’s inevitable that we’ll see pushback from those who benefit from the existing system. The points that Damore made in his now-infamous manifesto aren’t supported by the facts and are profoundly offensive to many, but in today’s world of “fake news” they’re fair game as “free speech.”Related: That Infamous Google Memo Says Plenty About What’s Wrong With Tech and Why It’s So Hard to Talk AboutLet’s be real: Women technologists and other minority tech workers face consistent, entrenched bias every single day. Damore’s screed is proof of that. Who wants to work with someone who clearly believes that gender makes them less qualified? Who wants to have that same person weighing in on their performance review? And who wants to be prejudged based on their gender before they’ve even walked in the door? I think we can all agree that every worker deserves to work in a harassment-free environment where they are evaluated based on their skills, abilities and accomplishments.Women leave technology careers at a rate twice as high as their male counterparts due to exactly this sort of bias, harassment and cultural hostility. Scandals like the Google memo make it doubly hard for girls and women to feel welcome as they pursue jobs at tech companies.Related: 3 Reasons Why Gender Equality is an ‘Everyone’ IssueWomen at Google are in a bind: Speaking out puts them at risk of being targeted. But now is exactly the right time for women and other marginalized technologists to tell their stories and make clear the daily human toll of bias and harassment. They need to talk about what they’ve achieved, and the reasons why they live and breathe for engineering and computer science. They need to share their dreams because, counter to prejudicial notions, women actually are ambitious, smart and, yes, even aggressive. They also must confront the bias they live with, along with a stunning lack of opportunity, advancement and recognition.Related: Uber Under Fire Once Again Following Sexism and Harassment ClaimsWe all need, now more than ever, to celebrate the women in our midst who are changing the tech world every day. Women and minority technologists will overcome these challenges by staying strong together, and forging stronger connections to the community. Together we can build a world where the people who create technology represent the societies that use it.  The Tech Industry’s Real Problem With Diversity Is Clear. It’s Not The Pipeline. Corporate Culture Image credit: Hero Images | Getty Imageslast_img read more

Oxidative stress could play key role in the spreading of aberrant proteins

first_imgOxidative stress has long been considered to be involved in the pathogenesis of Parkinson’s disease. Our work, however, reveals a new intriguing mechanism that may link oxidative stress to disease development. We show that under oxidative stress the propensity of alpha-synuclein to ‘travel’ from one neuron to the other is significantly enhanced, thus facilitating the exchange of harmful protein species, occurrence of pathology and the spreading of this pathology throughout the brain.”Professor Donato Di Monte, senior DZNE scientist, who headed the current research He adds, “Although in our study we induced oxidative stress artificially in laboratory models, we know that increased production of deleterious oxygen species could occur in Parkinson’s brain. It might be caused by a variety of conditions, such as genetic mutations and environmental exposures and might be related to the aging process itself, as some of the cellular mechanisms counteracting oxidative stress decline with age. Parkinson’s is an age-related disease, making it quite likely that aging brain cells would become more vulnerable to pathological processes involving oxidative stress.”Experimental settingRelated StoriesUTHealth researchers investigate how to reduce stress-driven alcohol useDogs and cats relieve academic stress and lift students’ mood, according to a new studyStudy reveals how genetic message to produce healthy heart tissue is altered during stress, agingIn a series of experiments, Di Monte and colleagues studied mice that overproduced alpha-synuclein in a specific brain region, namely the dorsal medulla oblongata, known to be a primary target of alpha-synuclein pathology in Parkinson’s disease. Under this condition, the researchers were able to show oxidative stress, formation of small alpha-synuclein aggregates (so called oligomers) and neuronal damage. Increased production of alpha-synuclein also led to its “jump” from donor neurons in the medulla oblongata into recipient neurons in neighboring brain regions that became affected by progressive alpha-synuclein accumulation and aggregation. Interestingly, treatment of mice with paraquat, a chemical agent that generates substantial amounts of reactive oxygen species and thus triggers an oxidative stress, exacerbated alpha-synuclein pathology and resulted in its more pronounced spreading throughout the brain.”Our findings support the hypothesis that a vicious cycle may be triggered by increased alpha-synuclein burden and oxidative stress,” Di Monte said. “Oxidative stress could promote the formation of alpha-synuclein aggregates which, in turn, may exacerbate oxidative stress. Jumping from neuron to neuron, this toxic process could affect more and more brain regions and contribute to progressive pathology and neuronal demise.”Abnormal proteinsThe precise mechanisms underlying enhanced neuron-to-neuron transfer of alpha-synuclein under oxidative stress are not fully understood. However, more detailed analyses by Di Monte and colleagues, including in-vitro experiments, revealed formation and accumulation of abnormal forms of alpha-synuclein that were oxidized and nitrated as a result of oxidative stress. These abnormal protein species were found to be particularly mobile and more prone to travel from donor to recipient cells.”Identification of toxic alpha-synuclein species with high propensity to aggregation and spreading bears significant implications,” Di Monte said. “They could be targeted for therapeutic intervention that may prevent early disease development and/or counteract the progression of pathology at later disease stages.” Source:DZNE – German Center for Neurodegenerative DiseasesJournal reference:Musgrove, R.E. et al. (2019) Oxidative stress in vagal neurons promotes parkinsonian pathology and intercellular α-synuclein transfer. Journal of Clinical Investigation. doi.org/10.1172/JCI127330. Reviewed by Kate Anderton, B.Sc. (Editor)Jul 17 2019Oxidative stress could be a driving force in the spreading of aberrant proteins involved in Parkinson’s disease. This is the result of lab studies by researchers of the German Center for Neurodegenerative Diseases (DZNE). The findings are published in the “Journal of Clinical Investigation”.Parkinson’s is a neurodegenerative disease with clinical manifestations that include motor (e.g., tremor and slowness in movements) as well as non-motor (e.g., sleep disorders and depression) symptoms. At the microscopic and pathological levels, the disease is characterized by accumulation of abnormal intraneuronal inclusions. They are formed as a result of aggregation of a protein called “alpha-synuclein”. In the course of the disease, these inclusions progressively appear in various brain regions, contributing to the gradual exacerbation of disease severity.The mechanisms behind this advancing pathology are poorly understood. Research by DZNE scientists now indicates that “oxidative stress”, i.e. an excessive and uncontrolled production of reactive oxygen species, could play an important role in the pathological spreading of alpha-synuclein. The findings are based on in-vivo studies with mice and in-vitro experiments in cultured cells.last_img read more

Team develops thermoelectric device that generates electricity using human body heat

first_img Power management circuits that amplify low voltages for efficient use of energy obtained from body temperature. Credit: The Electronics and Telecommunications Research Institute (ETRI) Provided by National Research Council of Science & Technology The Electronics and Telecommunications Research Institute (ETRI) in South Korea developed a thermoelectric module that generates electricity using human body heat. The module, which is 5 cm in width and 11 cm in length, can convert body heat energy into electricity and amplify it to power wearable devices. Wearing thermal electric devices that supply power based on body temperature are attached to the skin to illuminate the LED display. Credit: The Electronics and Telecommunications Research Institute (ETRI) When a patch-like structure is attached upon the thermoelectric device, a temperature difference occurs between the skin and the structure, imitating the sweat glands structure. This core technology is called “biomimetic heat sink.” It increases the output of the thermoelectric module by five times that of conventional products, maximizing the energy efficiency.The device also incorporates the power management integrated circuit technology that keeps efficiency above 80 percent even at low voltages and converts it to a chargeable voltage. In particular, the research team succeeded in generating a 35 microwatts per square centimeters (uW/cm2) output, which is 1.5 times higher than the 20 uW/cm2 output previously developed by U.S researchers.It has been confirmed that when six devices are modularized in a bundle, they can generate up to a commercialization level of 2~3 milliwatts (mW). Unlike disposable batteries, they can continuously generate energy from the human body temperature. In fact, the research team succeeded in lighting the letters “ETRI” on the LED display board by boosting the voltage generated from the six devices attached to the wrist of an adult without any batteries. Flexible thermoelectric generator module: a silver bullet to fix waste energy issuescenter_img Explore further In addition, a dry adhesion method that utilizes nano structure was used to attach to the skin contact area, whereas for the outer part of the module, micro structure was used to prevent easy tearing. This micro-nano hierarchical structure facilitate more stable adhesion on the human skin which have various roughness.The research team is currently carrying out a follow-up study to implement the power management circuit in one chip. The purpose of the study is to improve wearability in a moving situation while decreasing the discomfort of wearing patches. ETRI predicts the technology to be commercialized in two to three years. Citation: Team develops thermoelectric device that generates electricity using human body heat (2019, March 1) retrieved 17 July 2019 from https://phys.org/news/2019-03-team-thermoelectric-device-electricity-human.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

What Would You Do If We Found Aliens Survey Asks

first_img 13 Ways to Hunt Intelligent Aliens The quest to identify UFOs and even find intelligent life on other worlds has been heating up for decades … to no avail. But there are still plenty of spots and wavelengths where aliens could be hiding. So, what would humans do if we found concrete evidence that we are not alone in the universe? Turns out, there’s no real plan for how humanity would respond, let alone how we would deal with such a monumental discovery. The U.K. SETI Research Network (UKSRN) wants to change that by asking Earthlings their views on the search for aliens and how they’d react to a discovery. The network announced the survey, which it said is the largest such survey to date, yesterday (July 1) during the Royal Society’s Summer Science Exhibition, according to The Guardian. [Greetings, Earthlings! 8 Ways Aliens Could Contact Us] The online survey includes questions such as: AdvertisementFamous People Who Believe in AliensFrom pop stars to Hollywood actors to politicians, here are 13 famous people who believe in aliens.Volume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Better Bug Sprays?01:33 facebook twitter 发邮件 reddit 链接https://www.livescience.com/65848-alien-contact-seti-survey.html?jwsource=cl已复制直播00:0001:2601:26Your Recommended Playlist01:33Better Bug Sprays?04:24Sperm Whale Befriends Underwater Robot01:08Why Do French Fries Taste So Bad When They’re Cold?00:29Robot Jumps Like a Grasshopper, Rolls Like a Ball00:29Video – Giggly Robot02:31Surgical Robotics关闭  UFO Watch: 8 Times the Government Looked for Flying Saucers If we discover a signal from extraterrestrial intelligence, would you: — Not care much about it? — Just follow the news, comment? — Interact on social media about this topic? And this one: Some people think we should send messages into space even if we don’t receive a message first. What is your opinion? — This is a bad idea. We should ban people from sending messages. — There should be rules or laws about who can send messages and what they can say. — Anybody who wants to send a message into space should be allowed to do so. So, what are the odds we’d really need answers to these questions? To date, a lot of effort and money have gone into listening for alien signals. For instance, Breakthrough Listen’s team at the University of California, Berkeley’s SETI Research Center released 1 million gigabytes of data related to such a quest. The scientists had looked for anomalous pings in both radio and optical wavelengths emitted by 1,327 star systems. The result? None of those signals could be traced to anything other than human sources. Just this month, the Mutual UFO Network (MUFON) celebrated 50 years of looking for and studying UFO phenomenon. The nonprofit relies on volunteers to help find and identify these objects. Though the members insist that “we are not alone,” they have yet to spot conclusive evidence to support that claim. Even the U.S. government has suggested it’s serious about investigating bizarre craft of unknown origin. In 2017, the Pentagon confirmed that a secret “UFO” office — called the Advanced Aerospace Threat Identification Program — had spent $22 million over five years to study such baffling aeronautical reports. And even though funding ended in 2012, the program apparently remained alive. More recently, declassified videos have shown U.S. Navy pilots talking about seeing UFOs that demonstrated unexplainable properties. “Despite the fact that we [have] never detected a signal from extraterrestrial intelligence, this does not mean that it is never going to happen. What if it does?” Martin Dominik, an astrophysicist at the University of St. Andrews in the United Kingdom, told Live Science in an email. “The SETI community are currently rethinking this issue in the wake of the spread of social media and fake news. If there are consequences for the wider public, the decision about where to go becomes a political one rather than a scientific one,” said Dominik, who is also a UKSRN member. What have researchers learned so far from the survey responses? “I do not want to release any data at this moment, because it would bias the views of those who are still to respond,” Dominik said. Check out the survey and let the SETI group know what you’d do upon contact with extraterrestrial intelligence. 80 Years Ago, ‘News’ of an Alien Invasion Terrified Radio AudiencesEighty years ago today (Oct. 30), radio audiences were stunned by a purported news broadcast describing an “alien invasion” in New Jersey.Volume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Better Bug Sprays?01:33关闭选项Automated Captions – en-US facebook twitter 发邮件 reddit 链接https://www.livescience.com/65848-alien-contact-seti-survey.html?jwsource=cl已复制直播00:0002:1202:12Your Recommended Playlist01:33Better Bug Sprays?04:24Sperm Whale Befriends Underwater Robot01:08Why Do French Fries Taste So Bad When They’re Cold?00:29Robot Jumps Like a Grasshopper, Rolls Like a Ball00:29Video – Giggly Robot02:31Surgical Robotics关闭 center_img Originally published on Live Science.by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeVikings: Free Online GamePlay this for 1 min and see why everyone is addicted!Vikings: Free Online GameUndoInfinityKloudSmart USB Stick Backs Up Everything On Your Computer.InfinityKloudUndoTruthFinder People Search SubscriptionOne Thing All Liars Have in Common, Brace YourselfTruthFinder People Search SubscriptionUndoGundry MD Total Restore SupplementU.S. Cardiologist: It’s Like a Pressure Wash for Your InsidesGundry MD Total Restore SupplementUndoKelley Blue Book2019 Lexus Vehicles Worth Buying for Their Resale ValueKelley Blue BookUndoLivestlyThe List Of Dog Breeds To Avoid At All CostsLivestlyUndo 9 Strange, Scientific Excuses for Why Humans Haven’t Found Aliens Yetlast_img read more

Jaya cannot be termed a convict in assets case Madras HCJaya cannot

first_img COMMENT corruption & bribery SHARE SHARE EMAIL Tamil Nadu January 23, 2019 courts and legalcenter_img COMMENTS The Madras High Court on Wednesday held that former Tamil Nadu chief minister J Jayalalithaa cannot be termed a convict in a disproportionate assets case and dismissed a petition challenging the construction of a memorial for her on the ground that she was one.A Division Bench of justices M Sathyanarayanan and P Rajamanickam made the observation and dismissed the petition by ML Ravi, president of Desiya Makkal Sakthi Katchi, seeking a direction to restrain the Tamil Nadu government from spending money from the public exchequer for construction of the memorial.The petitioner also said steps should be taken to recover money if it was spent by the government from her property, citing that she was convicted in the disproportionate wealth case.‘Stigma of conviction’The Bench observed that before the orders could be passed by the Supreme Court on the appeals filed against the Karnataka High Court order, Jayalalithaa breathed her last and therefore, the appeal against her acquittal came to be dismissed as abated.“It is to be remembered at this juncture that the said person had already had the benefit of acquittal operating in her favour and in the light of the judgment of the HC, the stigma of conviction against her got erased, which has not been set aside by the apex court on merits for the reason that before the orders could be pronounced, she died.“Therefore, it cannot be said that Jayalalithaa was a convicted person and as such, there is a stigma of conviction attached to her,” the judges said. Published on SHARElast_img read more